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All diagnosis of relapses were supplemented by laboratory tests and were successfully retreated with FD MDT. By the end ofrelapses, or

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All diagnosis of relapses were supplemented by laboratory tests and were successfully retreated with FD MDT.

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By the end ofrelapses, or A ificant proportion of these relapses were confirmed by mouse footpad inoculation through demonstration of viable M. Mean value of the initial BI, i. Mean interval of relapse, i.

The information is useful for de the duration of follow-up for relapse after stopping treatment in clinical trials. Instituto Cree y Cirugia de Piel. Sobre un total de 6. Ganapati, V. Pai, CR. Revankar and HO. BuIchand Bombay Leprosy Project, Sion-Chunabhatti, Bombay - We report on what we believe to be the first case of relapse in multibacillary MB leprosy following short course chemotherapy for 28 days with daily doses of rifampicin R mg and ofloxacin O mg. The following diagram summarises the events relating to a ly untreated 30 year old male BL-LL patient with initial bacteriological index BI of, 4.

BI showed gradual decline accompanied by clinical regression. The patient remained negative and freee from 11 September Ganapati ;Ganapati et al, The case is under investigation for M. Leprae viability by mouse foot pad and drug sensitivity etc. The patient was HIV negative. The patient was treated with the same regimen of RO for 28 days under supervision and the relapsed clinical lesions are regressing. Currently the BI is 0. The satisfactory response to the same regimen so far indicates the possibility of "persisters" as the cause of relapse and not resistance to the drugs employed.

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The patient is under continuous observation. None of these have relapsed. Li Wenzhong. Shen Banlomg. Jiang Cheng. Paking union Medical College. Chinese Academy of Medical Sciences. Nanjing P. Among cases.

The chat avr of smear negativity In cases was The BI averagely decreased by 0. There were 2 relapsed cases with a relapse rata of 1. The 2 cases relapsed at the end of 3 and 4. But it is necessary to streng then the surveillance for MB cases after stopping MDT for collecting the valuable data yaozuxiag relapse.

Subjects: 41 patients who had completed WHO MDT and who had improved clinically, but whose bacteriological index Bl decreased by free naughty chat in salt lake than one log per year, were biopsied and assessed using the mouse-foot-pad assay system. Treatment was stopped and the patients were followed up. : M. In 2 cases, drug sensitivity could be assessed and the organisms were found to be fully sensitive to all three drugs used in the MDT regimen.

After yaizuxiang years without treatment, 9 of the 11 patients were traced and examined. They were all clinically inactive and had negative skin smears.

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Of the other two patients, one had died and the other could not be found. Conclusion: Viable bacilli can be isolated from some patients after completion of WHO MDT, but most patients can eliminate these bacilli without further chemotherapy and do not seem to be at great risk of relapse.

MDT has played a ificant role in the treatment ot leprosy. Few studies have investigated the viability of persisting M. Leprae in the nasal mucosa ot MB patients who had completed 2 years of MDT, using the mouse foot pad. Both biopsied tissues chhat mouse loot pad inoculation into Tr mice and wen; also studied histopathologically. Foot pad harvests were done on 6th, 9th and 12th months.

Except for one specimen from the skin of a lepromatous patient all inoculations showed no growth of bacteria in the mouse foot ohrny.

The extent of cellular infiltration varied. The study strengthens the belief that persistent M.

Leprae are not viable after 24 doses of MDT and lifestyle chat rooms that the nasaI mucosa of these patients do not harbour viable yaoauxiang. Gigi J. Histoid leprosy, an unusual variant of lepromatous leprosy, has been known to occur in untreated patients and in patients relapsing after dapsone mono-therapy. The unique occurrence ot histoid leprosy in a leprosy patient who had completed treatment with anti-leprosy multidrug therapy is being reported.

A 9-year old boy diagnosed as having borderline tuberculoid leprosy had treatment with dapsone mono-therapy for 3 years followed by 51 pulses of multi drug therapy. After being skin smear negative for 7 pussy chat aabenraa he presented with multiple discrote nodules in the upper and lower limbs and diffuse infiltration of the face. The nodules wore non-tender, shiny and firm. Histopathology of one of the skin nodules displayed dense compact granulomatous inflammation composed of spindle shaped macrophages arranged in a whorled pattern in the dermis with numerous clumps of acid fast bacilli that were long and solidly staining.

The clinicaI diagnosis of histoid leprosy was authenticrated histologically. Frer is the first report of leprosy relapsing as a histoid varioty after being treated with multidrug therapy. Viability and drug resistance studies on the Mycobacterium Leprae obtained from this patient are being carried out using the frew foot pad. Shetty V. Antia N. Pai V.

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The study included 36 multibacillary MB and 20 paucibacillary PB cases. While in all MB cases except 3 the relapse manifested in the form of borderline lepromatous BL lesions. The precise cause of recurrence of lesions could not be determined in 9 MB and 10 PB cases. The average incubation period for recurrence of lesions was ificantly lower among patients who had received fixed duration treatment 6 months for PB and 24 months for MB as compared to those who had received longer treatment. The MB cases guys chat room had received cortico steroid had frwe incubation period for relapse and among PB cases, there was a strong association between steroid intake and presence of viable bacteria.

Vtflahermosa, L. Dela Cruz. Philippines The objectives of this study are to determine the frequency of relapses in MB leprosy patients completing the 2 years WHO-MDT regimen and to determine whether the relapses that occur are vree to drug-resistant or to persisier organisms. They had no anu-lepriny treatment, finished the regimen wihin 24 to 30 months and no anti-leprosy treatment thereafter.

Duration of surveillance now ranee 4 to 11 years which include yearly clinical exannnaions and skin smears. Those found with probable relapse were biopsied and tested in mouse foot p or armadillo io confirm relapse. Drug-resistant studies were also done. The cluneal and bacteriological characteristics of the patients in the study - their skin smears before and after treatment and during the surveillance period - the clinical, bacteriological, histopathological characteristics as well as the yaozkxiang footpad and the response chat meet date hot women the relapse patients to alternative anti-leprosy treatment - will be discussed This study is funded by the Pacific Leprosy Foundation.

Jiu-si luo. Zheng and Da-ming Jiung Sichian provincial Institute of dertmatology.

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Chengdu City, Sichuan Province. Xishang City, Sichuan Province. Two thousand four hundred fifty four PB had nine hundred fifty four PB had completed the presenbed course of the treatment. Six cured persons affected by leprosy ly diagnosed as LL were identied as relapses clinically, bactenologicaly and frde in the surveillance period. Knuuttila Green Pastures Hospital, P. Box 28, Pokhara, Nepal Agranulocytosis is a recognised side effect of dapsone.

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There are many reports of agranulocytosis due to dapsone when used for malaria prophylaxis or treatment of dermatitis herpetiformis. There are cjat few reports of agranulocytosis during treatment of leprosy. In treatment of dermatitis herpetiformis agranulocytosis has been estimated to develop in 1 of to 42S patients treated and in malaria profylaxis in 1 of 10 to 20 persons. In spite of the large of people treated for leprosy with dapsone the of reported cases of agranulocytosis is very chat with teen online. The agranulocytosis develops usually during the first three months of treatment.

Three patients who developed dermatitis and agranulocytosis during treatment with MD T for leprosy hotny reported.

They developed agranulocytosis between 3 and 8 weeks after starting the treatment. One of them had exfoliative dermatitis like dermatitis, but affecting mainly the sun exposed areas of face, arms and ankles. Second had itching rashes all over the body with some scaling. Third had a full-blown exfoliative dermatitis. His neutrophil percentage normalised in 6 days.

His blood count normalised in 6 weeks. He fulfilled also the criteria for dapsone syndrome with enlarged liver, lympadenopathy and exfoliative dermatitis.

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